Understanding how proteins are modified by tyrosine phosphatases
Probing tyrosine phosphatase structure and function
This study is looking at how certain enzymes help control cell signals by changing proteins, which could help us understand more about how diseases like cancer work and find better treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11109190 on NIH RePORTER |
What this research studies
This research investigates the role of tyrosine phosphatases in cellular signaling, particularly how they modify proteins by removing phosphate groups. By developing new techniques, the research aims to uncover how these enzymes select their protein targets and how their activity is regulated in both healthy and diseased cells, especially in cancer. The approach includes creating a high-throughput biochemical platform to facilitate rapid analysis of these processes. This work could lead to a better understanding of the molecular mechanisms underlying various diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cancers where tyrosine phosphorylation plays a significant role in disease progression.
Not a fit: Patients with conditions unrelated to tyrosine phosphorylation or those not diagnosed with cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting tyrosine phosphatases, potentially improving treatment options for cancer patients.
How similar studies have performed: While there has been significant research on tyrosine kinases, the exploration of tyrosine phosphatases is less established, making this approach relatively novel.
Where this research is happening
New York, United States
- Columbia Univ New York Morningside — New York, United States (Active)
Researchers
- Principal investigator: Shah, Neel H — Columbia Univ New York Morningside
- Study coordinator: Shah, Neel H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.