Understanding how proteins are modified by arginylation and its role in heart development
Official title: Development and Application of Chemical Biology Approaches for Understanding Protein Arginylation
Funded at Washington University · NIH-11023790 · Data updated 2026-11-12
This study is looking at how a special process called arginylation affects proteins in the heart, which could help us understand heart development better and find new ways to treat heart diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | January 25, 2025 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $633,720 |
| NIH project number | 1R01HL177113-01 |
| Project ID | NIH-11023790 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who may have cardiovascular issues or are interested in heart health.
✕Less likely to help
Patients with non-cardiovascular conditions or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the process of arginylation, a modification of proteins that is crucial for heart and cardiovascular development. By using advanced chemical biology techniques, the study aims to identify and validate the proteins that undergo arginylation in cardiac tissues. The researchers will analyze heart cells and clinical samples to uncover the significance of these modifications in cardiovascular health. This work could lead to a better understanding of heart development and potential therapeutic targets for cardiovascular diseases.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for cardiovascular conditions related to protein modifications.
How similar studies have gone: While the specific approach of studying arginylation in cardiovascular development is relatively novel, related research in protein modifications has shown promising results in other contexts.
Where this research is happening
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Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Garcia, Benjamin a — Washington University
- Study coordinator: Garcia, Benjamin a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.