Understanding how proteins are modified after they are made in the body
A genetically encoded toolset to decipher the biology of post-translational modifications in the mammalian proteome
['FUNDING_OTHER'] · BOSTON COLLEGE · NIH-10833494
This study is exploring how proteins change after they're made, which can help scientists learn more about how these changes affect health and disease, and it's designed for researchers who want to better understand protein functions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON COLLEGE (nih funded) |
| Locations | 1 site (CHESTNUT HILL, UNITED STATES) |
| Trial ID | NIH-10833494 on ClinicalTrials.gov |
What this research studies
This research focuses on the various chemical modifications that proteins undergo after their synthesis, known as post-translational modifications (PTMs). By utilizing advanced genetic techniques, the study aims to create tools that allow scientists to incorporate specific modifications into proteins, enabling a better understanding of their functions in living organisms. The approach involves using mass-spectrometry to analyze these modifications and their effects on protein behavior in both laboratory settings and living systems. This could lead to significant insights into how proteins contribute to health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions linked to protein misfolding or dysfunction, such as certain genetic disorders or cancers.
Not a fit: Patients with conditions unrelated to protein modifications or those who do not have a genetic basis for their disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding diseases related to protein function and modification, potentially informing new treatment strategies.
How similar studies have performed: Other research has shown promising results using genetic code expansion techniques to study protein modifications, indicating a strong potential for success in this area.
Where this research is happening
CHESTNUT HILL, UNITED STATES
- BOSTON COLLEGE — CHESTNUT HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHATTERJEE, ABHISHEK — BOSTON COLLEGE
- Study coordinator: CHATTERJEE, ABHISHEK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.