Understanding how proteins are managed in cells to prevent diseases like ALS.
Official title: Architecture and function of condensates formed by ubiquitin-binding shuttle proteins and protein quality control components
Funded at Syracuse University · NIH-11088966 · Data updated 2026-11-12
This study is looking at how certain proteins in our cells help keep other proteins working properly, and it aims to understand how problems with these proteins might lead to diseases like ALS and frontotemporal dementia, with the hope of finding new ways to help patients manage these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Syracuse University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project start | June 1, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $467,599 |
| NIH project number | 1R35GM158070-01 |
| Project ID | NIH-11088966 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with amyotrophic lateral sclerosis or frontotemporal dementia.
✕Less likely to help
Patients with conditions unrelated to protein quality control or neurodegenerative diseases may not benefit from this research.
What this research studies
This research investigates the mechanisms of protein quality control (PQC) in cells, focusing on how certain proteins, known as ubiquitin-binding shuttle proteins, form condensates that help manage protein function. By studying these membraneless structures, the research aims to uncover how their dysregulation contributes to neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. The approach includes examining the interactions of these proteins under various conditions to understand their role in cellular stress responses and degradation processes. Patients may benefit from insights that could lead to new therapeutic strategies for managing these conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurodegenerative diseases by improving our understanding of protein management in cells.
How similar studies have gone: Previous research has shown promising results in understanding protein quality control mechanisms, suggesting potential for breakthroughs in treating related conditions.
Where this research is happening
-
Syracuse University
Syracuse, United States Active
Researchers
- Principal investigator: Castaneda, Carlos Antonio — Syracuse University
- Study coordinator: Castaneda, Carlos Antonio
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.