Understanding how proteins are managed at cell membranes
Proteostasis at cellular membranes
['FUNDING_OTHER'] · UNIVERSITY OF ILLINOIS AT CHICAGO · NIH-10890749
This study is looking at how the outer layers of our cells help control the recycling of proteins, which is important for keeping our cells healthy, especially when they face changes in their environment or when treated with medications, and it hopes to find new ways to help treat diseases like cancer and heart problems.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ILLINOIS AT CHICAGO (nih funded) |
| Locations | 1 site (Chicago, UNITED STATES) |
| Trial ID | NIH-10890749 on ClinicalTrials.gov |
What this research studies
This research investigates the role of cellular membranes in managing protein turnover, which is crucial for maintaining healthy cell function. It focuses on how proteins at these membranes are regulated by a system known as the ubiquitin-proteasome system (UPS), particularly in response to environmental changes and drug treatments. By studying specific proteins involved in this process, the research aims to uncover mechanisms that could be targeted for therapeutic interventions in diseases like cancer and cardiac disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cancer or cardiac disorders who may benefit from targeted therapies aimed at protein regulation.
Not a fit: Patients with conditions unrelated to protein turnover at cellular membranes or those not diagnosed with cancer or cardiac diseases may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating cancers and cardiac diseases by improving our understanding of protein regulation at cellular membranes.
How similar studies have performed: Previous research has shown promising results in targeting membrane proteins for therapeutic purposes, indicating that this approach has potential for success.
Where this research is happening
Chicago, UNITED STATES
- UNIVERSITY OF ILLINOIS AT CHICAGO — Chicago, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KUCHAY, SHAFI M. — UNIVERSITY OF ILLINOIS AT CHICAGO
- Study coordinator: KUCHAY, SHAFI M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, Cardiac Diseases, Cardiac Disorders