Understanding how proteins are maintained in the Golgi complex
Official title: Molecular mechanisms of membrane protein homeostasis at the Golgi
Funded at Cornell University · NIH-11066525 · Data updated 2026-11-12
This study is looking at how our cells recycle important proteins to keep everything running smoothly, which could help us understand more about health issues like cancer and certain genetic disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project start | July 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $375,716 |
| NIH project number | 5R35GM150863-03 |
| Project ID | NIH-11066525 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with congenital disorders of glycosylation or cancers that may be influenced by Golgi protein recycling mechanisms.
✕Less likely to help
Patients with conditions unrelated to Golgi function or those not affected by protein recycling mechanisms may not benefit from this research.
What this research studies
This research investigates the mechanisms that regulate the recycling of proteins within the Golgi complex, which is crucial for the proper functioning of cells. By using a combination of genetics, flow cytometry, imaging techniques, and proteomics, the researchers aim to uncover how specific proteins are selected for recycling and how these processes are controlled. The study focuses on understanding the implications of these mechanisms for human health, particularly in relation to diseases like cancers and congenital disorders of glycosylation.
Why it matters
Potential benefit: If successful, this research could lead to new insights and therapeutic strategies for treating cancers and genetic disorders linked to Golgi dysfunction.
How similar studies have gone: While the specific mechanisms being studied may be novel, previous research has shown that understanding cellular trafficking and protein recycling can lead to significant advancements in treating related diseases.
Where this research is happening
-
Cornell University
Ithaca, United States Active
Researchers
- Principal investigator: Sardana, Richa — Cornell University
- Study coordinator: Sardana, Richa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.