Understanding how proteins are made in mitochondria
Towards an Atomistic Understanding of Mitochondrial Protein Biogenesis
This study is looking at how proteins get into mitochondria, which are the powerhouses of our cells, to help us understand how to keep them healthy and possibly find better ways to treat diseases like cancer and neurodegenerative disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10874635 on NIH RePORTER |
What this research studies
This research investigates the processes involved in mitochondrial protein biogenesis, which is crucial for maintaining mitochondrial function and overall cell health. It focuses on the intricate mechanisms that allow proteins to be imported into mitochondria, where they play vital roles in energy production and cellular metabolism. By utilizing advanced techniques like cryo-electron microscopy, the research aims to uncover the complexities of mitochondrial architecture and the machinery responsible for protein import. This knowledge could lead to better understanding of diseases linked to mitochondrial dysfunction, such as certain cancers and neurodegenerative disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to mitochondrial dysfunction, including certain cancers and neurodegenerative disorders.
Not a fit: Patients with conditions unrelated to mitochondrial function or those who do not have any mitochondrial-related diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases associated with mitochondrial dysfunction.
How similar studies have performed: Other research has shown success in understanding mitochondrial function and its implications in disease, making this approach both relevant and promising.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Herzik, Mark Anthony — University of California, San Diego
- Study coordinator: Herzik, Mark Anthony
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.