Understanding how proteins are made in cells
Dynamics of Translation
['FUNDING_OTHER'] · STANFORD UNIVERSITY · NIH-11086770
This study is looking at how cells make proteins from their genetic instructions, using special tools to see this process in action, and it could help people understand how to better manage conditions related to protein production in both yeast and humans.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-11086770 on ClinicalTrials.gov |
What this research studies
This research investigates the complex process of translation, which is how cells produce proteins based on genetic information. By using advanced techniques like cryo-electron microscopy and single-molecule approaches, the team aims to observe the dynamic changes that occur during translation in real time. The study will focus on understanding how the ribosomal subunit binds to mRNA and how various factors influence this process in both yeast and human cells. Patients may benefit from insights gained into the regulation of protein synthesis, which is crucial for many biological functions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with genetic disorders or diseases that affect protein synthesis.
Not a fit: Patients with conditions unrelated to protein synthesis or translation processes may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases linked to protein synthesis errors.
How similar studies have performed: Previous research using similar methodologies has shown promise in understanding translation mechanisms, indicating that this approach could yield valuable insights.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PUGLISI, JOSEPH D — STANFORD UNIVERSITY
- Study coordinator: PUGLISI, JOSEPH D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.