Understanding how proteins are made and modified in nerve cells for growth and repair
Coupled axonal protein synthesis and lipidation in axon growth and homeostasis
This study is looking at how nerve cells grow and heal by understanding how they respond to signals around them, which is important for their health, and it’s designed for anyone interested in how our nervous system works.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10755700 on NIH RePORTER |
What this research studies
This research investigates how nerve cells, or axons, respond to signals in their environment during growth and repair. It focuses on the processes of protein synthesis and lipidation, which are crucial for the proper functioning of these cells. By using advanced imaging and biochemical techniques, the researchers aim to uncover how proteins are processed and localized in axons, particularly in response to growth signals. The study will involve both laboratory cultures and live animal models to provide a comprehensive understanding of these mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting nerve growth and repair, particularly those under 21 years old or adults experiencing nerve-related issues.
Not a fit: Patients with non-neurological conditions or those whose nerve function is not impacted may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing nerve repair and regeneration in patients with nerve injuries or neurodegenerative diseases.
How similar studies have performed: Previous research has shown promising results in understanding protein synthesis in nerve cells, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Kuruvilla, Rejji — Johns Hopkins University
- Study coordinator: Kuruvilla, Rejji
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.