Understanding how proteins are made and controlled in the body
Mechanism of Protein Synthesis and Translational Control
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11087639
This study is looking at how a specific protein, important for fragile X syndrome, helps control the way our bodies make other proteins, and it also explores how the flu virus makes its own proteins, with the hope of finding better ways to understand and treat these conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11087639 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms of protein synthesis and how certain proteins, particularly the fragile X mental retardation protein (FMRP), control this process. It focuses on two main areas: how FMRP regulates protein synthesis related to fragile X syndrome, which affects many children, and how the influenza A virus initiates its own protein production. By using advanced biochemical and biophysical methods, the research aims to uncover the detailed processes involved in these mechanisms, which could lead to better understanding and treatments for related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with fragile X syndrome or those affected by related conditions.
Not a fit: Patients with conditions unrelated to protein synthesis or those not affected by fragile X syndrome may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for fragile X syndrome and better antiviral strategies against influenza.
How similar studies have performed: Previous research has shown promising results in understanding protein synthesis mechanisms, particularly in relation to genetic disorders and viral infections.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JOSEPH, SIMPSON — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: JOSEPH, SIMPSON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: autism-fragile X (AFRAX) syndrome