Understanding how proteins are made and broken down in cells
Mechanistic dissection of eukaryotic protein biogenesis and degradation pathways
['FUNDING_OTHER'] · HARVARD UNIVERSITY · NIH-10923788
This study looks at how cells make and break down a special protein called eEF1A, which is important for cell health, and it aims to understand how mistakes in this process can lead to problems, with the hope of finding new insights that could help with diseases like COVID-19.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD UNIVERSITY (nih funded) |
| Locations | 1 site (CAMBRIDGE, UNITED STATES) |
| Trial ID | NIH-10923788 on ClinicalTrials.gov |
What this research studies
This research investigates the processes involved in the creation and degradation of proteins within cells, focusing on a specific chaperone system that aids in the formation of a key protein called eEF1A. It examines how errors in this protein's formation lead to its rapid breakdown and explores the mechanisms of selective autophagy, which is a process that removes damaged organelles from cells. By using both yeast and human cell cultures, the research aims to uncover the signals and pathways that regulate these critical cellular functions, potentially leading to insights into various diseases, including those related to COVID-19.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by conditions related to protein misfolding or degradation, such as certain neurodegenerative diseases or COVID-19.
Not a fit: Patients with conditions unrelated to protein biogenesis or degradation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases caused by protein misfolding and degradation, including COVID-19.
How similar studies have performed: Previous research has shown success in understanding protein degradation pathways, making this approach both relevant and promising.
Where this research is happening
CAMBRIDGE, UNITED STATES
- HARVARD UNIVERSITY — CAMBRIDGE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DENIC, VLADIMIR — HARVARD UNIVERSITY
- Study coordinator: DENIC, VLADIMIR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.