Understanding how proteins are degraded in the inner nuclear membrane
Inner nuclear membrane associated protein degradation
This study is looking at how certain proteins in yeast cells break down and how this process might affect aging and the health of the cell's nucleus, which could help us understand more about aging in cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida State University NIH-funded |
| Lab location | 1 site (Tallahassee, United States) |
| Project ID | NIH-10685951 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which proteins associated with the inner nuclear membrane are degraded, focusing on a specific pathway known as INMAD. By studying a protein called Mps3 in budding yeast, the researchers aim to uncover how this degradation process affects cell aging and the maintenance of the nuclear envelope. The study will involve identifying the factors that facilitate this protein degradation and understanding the consequences of its impairment. This research could provide insights into cellular aging and longevity.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in the biological mechanisms of aging and cellular health.
Not a fit: Patients with conditions unrelated to cellular aging or nuclear membrane dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for promoting healthy aging and longevity in human cells.
How similar studies have performed: While the specific approach of targeting INMAD in the context of aging is novel, similar research has shown promise in understanding protein degradation pathways in other cellular contexts.
Where this research is happening
Tallahassee, United States
- Florida State University — Tallahassee, United States (Active)
Researchers
- Principal investigator: Yu, Hong-Guo — Florida State University
- Study coordinator: Yu, Hong-Guo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.