Understanding how proteins are degraded in cells
Official title: Mechanisms of chaperone-mediated proteasomal degreadation
Funded at University of Missouri-Columbia · NIH-11128606 · Data updated 2026-11-12
This study is looking at how helper proteins work with a special machine in our cells to break down damaged proteins, which is important for keeping our cells healthy, and it could help us understand more about certain health issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project start | July 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $388,117 |
| NIH project number | 5R35GM155265-02 |
| Project ID | NIH-11128606 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to protein misfolding, such as certain cancers or neurodegenerative diseases.
✕Less likely to help
Patients with conditions unrelated to protein degradation or those who do not have protein misfolding disorders may not benefit from this research.
What this research studies
This research investigates the role of chaperone proteins in the process of protein degradation, specifically focusing on how they influence the 26S proteasome's ability to break down damaged or misfolded proteins. By employing a multi-disciplinary approach, the research aims to clarify the interactions between chaperones and the proteasome, which are crucial for maintaining protein quality control in cells. The study will utilize various in vitro techniques to explore these mechanisms, potentially shedding light on their implications for human health and disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases associated with protein misfolding and degradation.
How similar studies have gone: Other research has shown promising results in understanding protein degradation mechanisms, indicating that this approach has potential for significant advancements.
Where this research is happening
-
University of Missouri-Columbia
Columbia, United States Active
Researchers
- Principal investigator: Gates, Stephanie — University of Missouri-Columbia
- Study coordinator: Gates, Stephanie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.