Understanding how proteins are broken down in cells
Characterizing proteasome-substrate interactions by mass spectrometry proteomics
This study is looking at how a part of our cells called the proteasome breaks down proteins, which is important for keeping our cells healthy, and the findings could help us understand diseases that happen when this process goes wrong.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project ID | NIH-10815684 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which the proteasome, a critical cellular structure, degrades proteins. By using advanced techniques like cross-linking mass spectrometry and biochemical assays, the team aims to identify how proteins interact with the proteasome and how this process can be influenced. The collaboration between experts in bioanalytical chemistry and biochemistry will help uncover the molecular details of protein degradation, which is essential for maintaining cellular health. Patients may benefit from insights gained into how disruptions in this process can lead to diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions linked to proteostasis and protein degradation disorders.
Not a fit: Patients with conditions unrelated to protein degradation or those not experiencing any related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for diseases related to protein degradation.
How similar studies have performed: Previous research has shown promise in understanding proteasome function, indicating that this approach could yield valuable insights.
Where this research is happening
Bloomington, United States
- Trustees of Indiana University — Bloomington, United States (Active)
Researchers
- Principal investigator: Clemmer, David E. — Trustees of Indiana University
- Study coordinator: Clemmer, David E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.