Understanding how proteins are assembled and regulated in cells
Official title: Mechanisms of Chaperone-Mediated Control in the Assembly of the Proteasome
Funded at University of Colorado · NIH-11062377 · Data updated 2026-11-12
This study is looking at how certain helper proteins, called chaperones, help assemble other proteins in our cells, which is important for keeping our bodies healthy and could help us understand diseases like Alzheimer's and cancer better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado NIH-funded |
| Lab location | 1 site (Boulder, UNITED STATES) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $391,250 |
| NIH project number | 5R35GM153336-02 |
| Project ID | NIH-11062377 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related neurodegenerative conditions.
✕Less likely to help
Patients with non-neurodegenerative conditions or those not affected by protein misfolding disorders may not benefit from this research.
What this research studies
This research investigates the mechanisms by which proteins, specifically proteasomes, are assembled and regulated within cells. It focuses on the role of chaperones, which are proteins that assist in the proper assembly of other proteins, ensuring that they function correctly. By exploring how these chaperones control the assembly process and maintain quality control, the research aims to fill a significant knowledge gap in our understanding of protein degradation and its implications for diseases like Alzheimer's and cancer.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating neurodegenerative diseases and cancers by improving our understanding of protein regulation.
How similar studies have gone: Other research has shown promising results in understanding protein assembly and its implications for disease, indicating that this approach has potential for significant advancements.
Where this research is happening
-
University of Colorado
Boulder, United States Active
Researchers
- Principal investigator: Park, Soyeon — University of Colorado
- Study coordinator: Park, Soyeon
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.