Understanding how proteins and RNA separate inside cells to affect aging and disease
Multi-scale computational investigation of functions and mechanisms of protein-RNA phase separation.
This project explores how tiny structures inside our cells, made of proteins and RNA, change as we age and how these changes might lead to diseases like amyloid disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Iowa State University NIH-funded |
| Lab location | 1 site (Ames, United States) |
| Project ID | NIH-11091234 on NIH RePORTER |
What this research studies
Our cells contain special compartments called condensates, formed when proteins and RNA separate from their surroundings, which are crucial for many cell functions. These condensates can behave like soft gels or liquids, but their properties can change over time, especially with aging. Sometimes, these changes can cause them to become solid and harmful, like the amyloid deposits seen in certain diseases. This work uses advanced computer models to figure out the molecular rules that control these condensate properties and how they influence important cell processes and disease development.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit individuals affected by age-related conditions and diseases involving amyloid formation.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not find direct benefit from participating in this basic science project.
Why it matters
Potential benefit: If successful, this work could provide a deeper understanding of how aging contributes to diseases like amyloid disorders, potentially leading to new ways to prevent or treat them.
How similar studies have performed: While the existence and dynamic behaviors of these cellular condensates are known, this project offers a novel computational approach to decipher the specific molecular rules governing their properties and impact on disease.
Where this research is happening
Ames, United States
- Iowa State University — Ames, United States (Active)
Researchers
- Principal investigator: Potoyan, Davit — Iowa State University
- Study coordinator: Potoyan, Davit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.