Understanding how proteins and nucleic acids interact in microbes
Deciphering fundamental biological processes involving protein-nucleic acid interactions at the molecular level
['FUNDING_OTHER'] · DUKE UNIVERSITY · NIH-10993201
This study is looking at how proteins and DNA work together in bacteria to help them survive in their surroundings, which could lead to new ways to fight antibiotic-resistant infections.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-10993201 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular principles behind how proteins and nucleic acids interact, particularly in microbes. By focusing on processes such as transcription and DNA organization, the research aims to uncover how bacteria sense and respond to their environment, which is crucial for their survival. The findings could lead to the identification of new targets for antimicrobial agents, addressing the urgent need for new treatments against antimicrobial-resistant bacteria. The research employs advanced techniques like cryo-electron microscopy to visualize these interactions at the atomic level.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from infections caused by antimicrobial-resistant bacteria.
Not a fit: Patients with infections that are not caused by bacterial pathogens may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antimicrobial agents that effectively combat resistant bacterial infections.
How similar studies have performed: Other research has shown success in targeting protein-nucleic acid interactions to develop new antimicrobial strategies, indicating that this approach has potential.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHUMACHER, MARIA — DUKE UNIVERSITY
- Study coordinator: SCHUMACHER, MARIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.