Understanding how proteins and nucleic acids form and behave in cell compartments.
Inside Condensates: Bridging molecular structure and condensate material properties through simulation
['FUNDING_OTHER'] · PRINCETON UNIVERSITY · NIH-10940007
This study is exploring how tiny, droplet-like structures in our cells, made of proteins and genetic material, form and work, with the hope of learning more about their role in health issues like cancer and brain diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PRINCETON UNIVERSITY (nih funded) |
| Locations | 1 site (Princeton, UNITED STATES) |
| Trial ID | NIH-10940007 on ClinicalTrials.gov |
What this research studies
This research investigates the formation and properties of biomolecular condensates, which are membraneless compartments in cells made up of proteins and nucleic acids. By using advanced computer modeling and simulations, the research aims to elucidate the molecular structures and interactions that sustain these condensates. The goal is to improve our understanding of how these structures influence health and disease, particularly in conditions like cancer and neurodegenerative disorders. This approach seeks to overcome the limitations of traditional experimental methods, making it easier to evaluate the properties of condensates systematically.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by cancers or neurodegenerative disorders, as well as those with other diseases linked to biomolecular condensates.
Not a fit: Patients with conditions unrelated to biomolecular condensates or those not affected by the diseases being studied may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into disease mechanisms and the development of targeted therapies for various health conditions.
How similar studies have performed: Previous research has shown success in using computer models to study disordered proteins in condensates, indicating that this approach has potential for further advancements.
Where this research is happening
Princeton, UNITED STATES
- PRINCETON UNIVERSITY — Princeton, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JOSEPH, JERELLE AURELIA — PRINCETON UNIVERSITY
- Study coordinator: JOSEPH, JERELLE AURELIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, Communicable Diseases, Degenerative Neurologic Disorders, Disease, Disorder