Understanding how proteins and membranes are transported within cells.
Coordination of intracellular trafficking pathways by Ypt/Rab GTPases and their GEFs.
This study is looking at how tiny proteins help move things around inside cells, which is important for understanding diseases like cancer, and it's using yeast to figure out how these processes work together.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-11075250 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which proteins and membranes are transported inside cells through three main pathways: exocytosis, endocytosis, and autophagy. By studying Ypt/Rab GTPases and their nucleotide exchangers (GEFs), the research aims to uncover how these proteins coordinate various transport processes. Using yeast as a model organism, the team will explore how these pathways interact and function together, which could provide insights into cellular processes relevant to diseases like cancer. The approach involves detailed biochemical analyses and genetic studies to understand the roles of these proteins in cellular trafficking.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to cellular transport disorders or cancers that may benefit from improved understanding of cellular mechanisms.
Not a fit: Patients with conditions unrelated to cellular transport or those not affected by cancer may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases related to cellular transport dysfunction, including certain cancers.
How similar studies have performed: Previous research has shown success in understanding cellular transport mechanisms, making this approach a continuation of established scientific inquiry.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Segev, Nava — University of Illinois at Chicago
- Study coordinator: Segev, Nava
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.