Understanding how proteins affect brain function in Alzheimer's disease.
Neural Circuit Disruption in Freely-Behaving models of Alzheimer's Disease.
This study looks at how certain proteins related to Alzheimer's disease affect brain function in animals, helping us learn more about the disease and find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11080892 on NIH RePORTER |
What this research studies
This research investigates the impact of amyloid beta (Aβ) and tau proteins on brain function in Alzheimer's disease by using advanced technologies to observe freely behaving animal models. The study aims to understand how these proteins disrupt neural circuits and how their effects vary depending on the animal's behavior. By comparing models of early and late-onset Alzheimer's disease, the research seeks to provide insights into the mechanisms of the disease and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for Alzheimer's disease, particularly those with genetic predispositions or early symptoms.
Not a fit: Patients with advanced Alzheimer's disease or those without genetic risk factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding Alzheimer's mechanisms using similar animal models, indicating potential for success in this approach.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Gomperts, Stephen N. — Massachusetts General Hospital
- Study coordinator: Gomperts, Stephen N.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.