Understanding how protein synthesis starts and is controlled in human cells
From one end to the other: dynamics of human translation initiation and its control
['FUNDING_OTHER'] · FRED HUTCHINSON CANCER CENTER · NIH-10930141
This study is looking at how our cells start making proteins, which is really important for keeping us healthy, and it aims to understand how this process goes wrong in diseases like cancer and neurological disorders, so that we can find better ways to help patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | FRED HUTCHINSON CANCER CENTER (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10930141 on ClinicalTrials.gov |
What this research studies
This research investigates the complex process of protein synthesis initiation in human cells, which is crucial for proper cellular function. It focuses on how ribosomes, the machinery that produces proteins, are recruited to messenger RNA (mRNA) and how this process is regulated by various proteins. By using advanced techniques like single-molecule spectroscopy and structural analyses, the research aims to uncover the dynamics of these interactions and their implications for diseases such as cancer and neurological disorders. Patients may benefit from insights gained into how disruptions in this process contribute to various health conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by cancers, developmental disorders, or neurological diseases.
Not a fit: Patients with conditions unrelated to protein synthesis or those not affected by the diseases being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases linked to protein synthesis dysregulation.
How similar studies have performed: Other research has shown success in understanding protein synthesis mechanisms, indicating that this approach has potential for significant findings.
Where this research is happening
SEATTLE, UNITED STATES
- FRED HUTCHINSON CANCER CENTER — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LAPOINTE, CHRISTOPHER PAUL — FRED HUTCHINSON CANCER CENTER
- Study coordinator: LAPOINTE, CHRISTOPHER PAUL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers