Understanding how protein synthesis is controlled in humans
Official title: Mechanisms of Translation Control in Humans
Funded at University of California Berkeley · NIH-11030763 · Data updated 2026-11-12
This study is looking at how a special factor in our cells helps make proteins, especially in immune cells, and it hopes to find new ways to treat diseases that happen when protein production goes wrong.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | March 7, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $547,489 |
| NIH project number | 5R35GM148352-03 |
| Project ID | NIH-11030763 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to immune response or protein synthesis disorders.
✕Less likely to help
Patients with conditions unrelated to protein synthesis or immune function may not benefit from this research.
What this research studies
This research investigates the mechanisms that regulate protein synthesis, specifically focusing on translation initiation and elongation in human cells. The team will explore how a key factor, eukaryotic initiation factor 3 (eIF3), influences the translation of specific messenger RNAs (mRNAs) in various tissues, including activated T cells. By employing molecular and structural biology techniques, the researchers aim to uncover the interactions between eIF3 and RNA elements that dictate protein production. The findings could lead to new insights into treating diseases linked to protein synthesis dysregulation.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies for diseases caused by faulty protein synthesis.
How similar studies have gone: Previous research has shown promising results in understanding translation mechanisms, suggesting potential for breakthroughs in this area.
Where this research is happening
-
University of California Berkeley
Berkeley, United States Active
Researchers
- Principal investigator: Cate, Jamie H — University of California Berkeley
- Study coordinator: Cate, Jamie H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.