Understanding how protein structures relate to diseases
Unlocking sequence-structure-function-disease relationships in large protein super-families
This study is looking at how the genes that make proteins relate to how those proteins work and their roles in diseases, especially in older adults, to help understand and predict health issues better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project ID | NIH-11014427 on NIH RePORTER |
What this research studies
This research investigates the connections between the genetic sequences of proteins and their structures, functions, and roles in diseases, particularly focusing on protein super-families like kinases. By using both computational models and experimental methods, the team aims to uncover how these proteins can influence disease outcomes, especially in age-related conditions. The research also explores the unique regulatory mechanisms of certain proteins and how they can be used to predict disease phenotypes from genetic information.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with age-related diseases or conditions that may be influenced by protein function and regulation.
Not a fit: Patients with non-age-related diseases or those not affected by protein kinases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved predictions of disease risks and better-targeted therapies for patients with age-related disorders.
How similar studies have performed: Other research has shown success in understanding protein functions and their implications in diseases, making this approach promising yet still innovative.
Where this research is happening
Athens, United States
- University of Georgia — Athens, United States (Active)
Researchers
- Principal investigator: Kannan, Natarajan — University of Georgia
- Study coordinator: Kannan, Natarajan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.