Understanding how protein structures affect their functions
Deciphering structure-function relationship in large protein complexes by modeling
['FUNDING_OTHER'] · IBM THOMAS J. WATSON RESEARCH CENTER · NIH-10840685
This study is looking at how big protein groups in bacteria work and fit together, using special imaging tools to help us understand their roles better, which could eventually lead to new treatments for related health issues.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | IBM THOMAS J. WATSON RESEARCH CENTER (nih funded) |
| Locations | 1 site (YORKTOWN HEIGHTS, UNITED STATES) |
| Trial ID | NIH-10840685 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between the structure and function of large protein complexes, particularly in bacteria. By utilizing advanced imaging techniques like Cryo-electron microscopy, the project aims to develop mathematical models that can explain how these protein structures operate and interact. The goal is to bridge the gap between structural data and functional understanding, focusing on specific complexes that play crucial roles in cellular processes. Patients may benefit from insights gained about these biological systems, which could lead to advancements in treatments for related conditions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with bacterial infections or related conditions influenced by protein complex functions.
Not a fit: Patients with conditions unrelated to bacterial functions or protein complex dynamics may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting bacterial functions and diseases.
How similar studies have performed: Other research has shown success in using structural biology and mathematical modeling to understand protein functions, indicating a promising approach.
Where this research is happening
YORKTOWN HEIGHTS, UNITED STATES
- IBM THOMAS J. WATSON RESEARCH CENTER — YORKTOWN HEIGHTS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TU, YUHAI — IBM THOMAS J. WATSON RESEARCH CENTER
- Study coordinator: TU, YUHAI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.