Understanding how protein signaling affects cell behavior at a single-cell level
Interrogation and interpretation of protein kinase signaling dynamics at single-cell resolution
This study is looking at how certain proteins in your cells react to cancer treatments, using new techniques to see these reactions up close, with the hope of finding better ways to help patients like you respond to therapy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10864058 on NIH RePORTER |
What this research studies
This research investigates the dynamic behaviors of protein kinase signaling, which are crucial for determining how cells respond to various treatments, including cancer therapies. By utilizing innovative chemical methods and imaging probes, the study aims to analyze these signaling dynamics in individual cells, overcoming previous technological limitations. The goal is to link specific signaling patterns to different cell outcomes, such as survival or death in response to drugs, which could lead to more effective treatment strategies for cancer patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cancers that are influenced by protein kinase signaling, such as glioblastoma.
Not a fit: Patients with conditions unrelated to protein kinase signaling dynamics may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer treatment strategies by predicting how individual cells will respond to therapies.
How similar studies have performed: Other research has shown promising results in understanding kinase signaling dynamics, indicating that this approach has potential for significant advancements in cancer treatment.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Xue, Min — Icahn School of Medicine at Mount Sinai
- Study coordinator: Xue, Min
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.