Understanding how protein sequences affect their functions
Official title: Development of large-scale sequence-function relationship using in situ optical sequencing
Funded at University of Oklahoma Hlth Sciences Ctr · NIH-10920356 · Data updated 2026-11-12
This study is exploring how different protein sequences work, which could help create better treatments and tests for patients by improving our understanding of how proteins function.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | September 15, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $176,600 |
| NIH project number | 5R21GM148901-03 |
| Project ID | NIH-10920356 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with conditions that could be treated or diagnosed using advanced protein tools.
✕Less likely to help
Patients with conditions unrelated to protein functionality or those not requiring protein-based interventions may not receive benefits from this research.
What this research studies
This research focuses on uncovering the relationship between protein sequences and their functions, which is crucial for advancing biological tools used in various fields. By developing a method for large-scale sequencing and functional analysis of proteins, the project aims to enhance our ability to predict and design effective protein tools. Patients may benefit from improved therapies and diagnostics that arise from a better understanding of protein functionality. The research employs advanced optical sequencing techniques to analyze a vast array of protein variants, overcoming current limitations in the field.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective protein-based therapies and diagnostic tools for various diseases.
How similar studies have gone: Other research has shown success in similar approaches, indicating the potential for significant advancements in understanding protein functions.
Where this research is happening
-
University of Oklahoma Hlth Sciences Ctr
Oklahoma City, United States Active
Researchers
- Principal investigator: Gong, Yiyang — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Gong, Yiyang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.