Understanding how Protein S controls blood clotting
Protein S Regulates Blood Coagulation by Inhibiting Factor IXa
This study is looking at how a protein called Protein S helps keep your blood from clotting too much, which is important for people who have issues with blood clots, like deep vein thrombosis or pulmonary embolism, and aims to find new treatments for those conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lsu Health Sciences Center NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-11075778 on NIH RePORTER |
What this research studies
This research investigates the role of Protein S, a crucial anticoagulant in the blood, in regulating blood coagulation by inhibiting Factor IXa, which is involved in clot formation. The study aims to explore the biochemical interactions between Protein S and Factor IXa to understand how deficiencies in Protein S can lead to serious thrombotic conditions like deep vein thrombosis and pulmonary embolism. By identifying the specific binding sites and mechanisms involved, the researchers hope to develop a therapeutic agent that could help patients with excessive blood clotting or Protein S abnormalities. The research employs both in vivo and in vitro methodologies to achieve these goals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with Protein S deficiencies or those experiencing excessive blood clotting.
Not a fit: Patients with normal Protein S levels and no history of blood clotting disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from blood clotting disorders.
How similar studies have performed: Previous research has shown promising results in understanding anticoagulant mechanisms, suggesting potential for success in this novel approach.
Where this research is happening
New Orleans, United States
- Lsu Health Sciences Center — New Orleans, United States (Active)
Researchers
- Principal investigator: Majumder, Rinku — Lsu Health Sciences Center
- Study coordinator: Majumder, Rinku
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.