Understanding how protein quality control affects aging and related diseases
Protein quality control in age-related diseases
This study is looking at how a special enzyme called CHIP helps keep proteins in our cells healthy as we age, which could lead to better understanding and treatments for conditions like Alzheimer's disease and other age-related issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11055732 on NIH RePORTER |
What this research studies
This research investigates the role of protein quality control in age-related diseases, particularly focusing on how proteins fold and are degraded within cells. The study examines a specific enzyme, CHIP, which is crucial for maintaining protein integrity and is linked to various degenerative conditions, including Alzheimer's disease. By exploring how CHIP influences key cellular processes, the research aims to uncover mechanisms that could lead to better understanding and potential treatments for age-related cognitive decline and other disorders. Patients may benefit from insights into how protein management can impact their health as they age.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults aged 21 and older who are experiencing symptoms of age-related cognitive decline or have a family history of Alzheimer's disease.
Not a fit: Patients who are younger than 21 or do not have any age-related cognitive issues may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating age-related diseases, particularly Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding protein quality control mechanisms in other degenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Schisler, Jonathan C. — Univ of North Carolina Chapel Hill
- Study coordinator: Schisler, Jonathan C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.