Understanding how protein networks influence cell membrane shape
Protein Networks as Synergistic Drivers of Membrane Remodeling
This study is looking at how certain proteins help shape the outer layer of our cells, which is important for how cells work, especially in conditions like cancer and diabetes, to better understand how these processes can go wrong and potentially help patients in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas at Austin NIH-funded |
| Lab location | 1 site (Austin, United States) |
| Project ID | NIH-11256417 on NIH RePORTER |
What this research studies
This research investigates the role of protein networks in shaping cell membranes, which is crucial for various cellular functions. By focusing on how disordered protein domains contribute to membrane curvature, the study aims to uncover the underlying mechanisms that affect processes like receptor recycling in diseases such as cancer and diabetes. The approach involves examining clathrin-mediated endocytosis to understand how these protein networks facilitate membrane remodeling. Patients may benefit from insights gained about cellular processes that are disrupted in their conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by conditions that involve membrane remodeling issues, particularly those with cancer or diabetes.
Not a fit: Patients with conditions unrelated to membrane curvature or cellular physiology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases linked to membrane curvature defects, such as cancer and diabetes.
How similar studies have performed: Previous research has shown promising results in understanding protein interactions and membrane dynamics, indicating that this approach could yield valuable insights.
Where this research is happening
Austin, United States
- University of Texas at Austin — Austin, United States (Active)
Researchers
- Principal investigator: Stachowiak, Jeanne Casstevens — University of Texas at Austin
- Study coordinator: Stachowiak, Jeanne Casstevens
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.