Understanding how protein movements affect their functions
Mechanisms and dynamics of allosteric function in proteins
['FUNDING_OTHER'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-11095310
This study is looking at how proteins move and change their activity, especially when they interact with other molecules, to help us better understand how they work and potentially create new treatments for diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-11095310 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between the movements of proteins and their functions, particularly focusing on allosteric regulation, which is how proteins can change their activity in response to binding at sites other than their active sites. The study employs advanced techniques like NMR and biophysical methods to explore natural allosteric enzymes and aims to engineer new allosteric functions into signaling proteins. By understanding these dynamics, the research seeks to enhance our knowledge of protein behavior, which could lead to improved drug design and therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cancers that may be treated with drugs targeting allosteric sites on proteins.
Not a fit: Patients with non-cancerous conditions or those whose cancers do not involve the proteins being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective cancer treatments by improving the design of drugs that target specific protein functions.
How similar studies have performed: Other research has shown promising results in understanding protein dynamics and allostery, indicating that this approach has potential for significant advancements in drug discovery.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEE, ANDREW L — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: LEE, ANDREW L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Anti-Cancer Agents