Understanding how protein modifications help human cells respond to stress
Characterizing new redox roles for protein ubiquitination in human cells
This study looks at how our cells handle stress from things like UV rays and pollution, focusing on a special protein called ubiquitin that helps control other proteins during tough times, with the goal of finding ways to help cells stay strong and healthy.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10371928 on NIH RePORTER |
What this research studies
This research investigates how human cells manage oxidative stress caused by environmental factors like UV radiation and pollutants. It focuses on the role of ubiquitin, a protein that modifies other proteins to control their function and fate, particularly during stress responses. The study aims to uncover the mechanisms by which ubiquitin helps cells survive under stress by regulating protein production and degradation. By examining the specific ubiquitin enzymes involved, the research seeks to provide insights into cellular resilience and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to oxidative stress, such as cancer or chronic diseases.
Not a fit: Patients with acute conditions unrelated to oxidative stress may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing cellular resilience against stress, potentially benefiting patients with chronic diseases or cancers.
How similar studies have performed: Other research has shown promising results in understanding the role of ubiquitin in stress responses, indicating that this approach has potential for significant findings.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Silva, Gustavo M — Duke University
- Study coordinator: Silva, Gustavo M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.