Understanding how protein modifications affect neurological disorders
Official title: Protein ubiquitination and deubiquitination in neurological disorders
Funded at Georgia State University · NIH-11045097 · Data updated 2026-11-12
This study is looking at how certain proteins in the brain help keep it healthy and how changes in these proteins might be connected to neurological disorders like Gordon Holmes syndrome, with the goal of finding new ways to understand and treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgia State University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | September 13, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $390,000 |
| NIH project number | 1R56NS136464-01 |
| Project ID | NIH-11045097 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with neurological disorders, particularly those with mutations related to ubiquitination processes.
✕Less likely to help
Patients without neurological disorders or those not carrying relevant genetic mutations may not benefit from this research.
What this research studies
This research investigates the role of protein ubiquitination and deubiquitination in the nervous system, which are crucial processes for maintaining healthy brain function. The study focuses on specific enzymes involved in these modifications and how mutations in these enzymes are linked to various neurological disorders, such as Gordon Holmes syndrome. By using advanced proteomics techniques, the researchers aim to identify the interactions and effects of these proteins in both healthy and diseased states. This could lead to a better understanding of the underlying mechanisms of neurological conditions and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for patients suffering from neurological disorders linked to protein modifications.
How similar studies have gone: Previous research has shown promising results in understanding the role of protein modifications in other neurological conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Georgia State University
Atlanta, United States Active
Researchers
- Principal investigator: Mabb, Angela M — Georgia State University
- Study coordinator: Mabb, Angela M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.