Understanding how protein modifications affect human papillomavirus behavior
The role of asymmetric protein dimethylation during the human papillomavirus lifecycle
This study is looking at how a specific protein affects the way the HPV virus interacts with our cells, which could help us understand how to prevent HPV-related cancers like cervical cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project ID | NIH-10852863 on NIH RePORTER |
What this research studies
This research investigates the role of protein dimethylation in the lifecycle of human papillomavirus (HPV), which is linked to various cancers, including cervical cancer. By using advanced single-cell genomics, the study aims to uncover how HPV interacts with host cells and what factors contribute to the persistence of the virus in the body. The researchers focus on a specific protein, PRMT1, which appears to influence the viral infection process and its long-term effects. This could lead to new insights into preventing HPV-related cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with persistent HPV infections, particularly those at risk for cervical or other anogenital cancers.
Not a fit: Patients who have cleared HPV infections or do not have a history of HPV-related cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating HPV-related cancers.
How similar studies have performed: Other research has shown promising results in understanding viral persistence and its implications for cancer, making this approach both relevant and potentially impactful.
Where this research is happening
Tucson, United States
- University of Arizona — Tucson, United States (Active)
Researchers
- Principal investigator: Van Doorslaer, Koenraad — University of Arizona
- Study coordinator: Van Doorslaer, Koenraad
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.