Understanding how protein modifications affect gene regulation in cancer
Mechanistic studies of chromatin modification in transcription regulation
This study is looking at how changes to proteins that help package our DNA can affect how genes work and how our bodies fix DNA, especially in cancer, with the hope of finding new ways to create better treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11051813 on NIH RePORTER |
What this research studies
This research investigates how specific modifications to histone proteins, which package DNA, influence gene expression and DNA repair. By focusing on the role of ubiquitin attachment to histones, the study aims to uncover the molecular mechanisms that regulate these processes, particularly in the context of cancer. Utilizing advanced techniques like cryo-electron microscopy and biochemistry, the research seeks to identify how these modifications interact and affect transcription. The ultimate goal is to inform the development of new drugs that target these molecular pathways to improve cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cancers characterized by misregulation of histone modifications, such as acute lymphoblastic leukemia.
Not a fit: Patients with cancers not associated with histone modification dysregulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel therapies that more effectively target cancer by manipulating gene regulation.
How similar studies have performed: Other research has shown promising results in targeting histone modifications for cancer treatment, indicating that this approach has potential for success.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Wolberger, Cynthia — Johns Hopkins University
- Study coordinator: Wolberger, Cynthia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.