Understanding how protein modifications affect diseases like cancer and diabetes
Official title: Mechanism and Inhibition of Histone Modifications
Funded at University of Georgia · NIH-11013891 · Data updated 2026-11-12
This study is looking at how certain proteins in our cells can affect health and diseases like cancer and diabetes, with the goal of finding new ways to treat these conditions and help patients feel better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project start | April 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $335,675 |
| NIH project number | 5R35GM149230-03 |
| Project ID | NIH-11013891 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with cancer, diabetes, or other related disorders influenced by protein methylation.
✕Less likely to help
Patients with conditions unrelated to protein methylation or those not diagnosed with cancer or diabetes may not benefit from this research.
What this research studies
This research investigates the role of protein methylation, specifically on arginine and lysine residues, in various cellular processes that are crucial for health and disease. By exploring how protein methyltransferases influence gene expression, metabolism, and signaling pathways, the research aims to uncover their contributions to diseases such as cancer, diabetes, and inflammation. The team will employ innovative chemical biology techniques to identify new therapeutic targets and develop potential treatments. Patients may benefit from insights gained into disease mechanisms and the development of targeted therapies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases like cancer and diabetes by targeting specific protein modifications.
How similar studies have gone: Previous research has shown promising results in targeting protein methyltransferases for therapeutic purposes, indicating a potential for success in this area.
Where this research is happening
-
University of Georgia
Athens, United States Active
Researchers
- Principal investigator: Zheng, Y. George — University of Georgia
- Study coordinator: Zheng, Y. George
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.