Understanding how protein modifications affect cell survival under stress
Dissecting the roles of ubiquitin in translation control
['FUNDING_OTHER'] · DUKE UNIVERSITY · NIH-10912579
This study is looking at how a special protein modification helps cells make the proteins they need to survive when they're under stress, like when they're exposed to harmful conditions, and it could lead to new ways to support health and fight diseases related to this stress.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-10912579 on ClinicalTrials.gov |
What this research studies
This research investigates how the modification of proteins by ubiquitin influences protein synthesis and the survival of cells when they face oxidative stress. The study focuses on the role of a specific type of ubiquitin modification, known as K63-linked ubiquitin, in regulating ribosomes, which are crucial for protein production. By employing advanced molecular and proteomics techniques, the researchers aim to uncover the mechanisms that allow cells to adapt their protein expression in response to damaging conditions. This understanding could lead to new strategies for promoting health and combating diseases linked to cellular stress.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by neurodegenerative disorders or conditions related to oxidative stress.
Not a fit: Patients with conditions unrelated to oxidative stress or protein synthesis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for neurodegenerative diseases and other conditions caused by cellular stress.
How similar studies have performed: Previous research has shown promising results in understanding the role of ubiquitin in cellular processes, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SILVA, GUSTAVO M — DUKE UNIVERSITY
- Study coordinator: SILVA, GUSTAVO M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.