Understanding how protein modifications affect cancer development
Deciphering the physiological role and interplay between ubiquitination and phosphorylation pathways to guide targeted cancer therapies
This study is looking at how certain changes to proteins in our cells can affect cancer growth, with the goal of finding new ways to treat different types of cancer, so patients can learn more about their condition and how to fight it better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10892051 on NIH RePORTER |
What this research studies
This research investigates the roles of two important protein modification pathways, ubiquitination and phosphorylation, in cancer development. By studying how these modifications influence cell signaling and the cell cycle, the research aims to identify new targets for cancer therapies. The approach involves analyzing complex protein interactions and their effects on tumor growth, which could lead to more effective treatments for various cancers. Patients may benefit from insights gained into how their cancer develops and how it can be treated more effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with various types of cancer who may benefit from novel targeted therapies.
Not a fit: Patients with non-cancerous conditions or those whose cancers are not influenced by the pathways being studied may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that more effectively treat cancer by addressing the underlying mechanisms of tumorigenesis.
How similar studies have performed: Previous research has shown success in targeting similar protein modification pathways for cancer treatment, indicating a promising avenue for further exploration.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Wei, Wenyi — Beth Israel Deaconess Medical Center
- Study coordinator: Wei, Wenyi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.