Understanding how protein fibrils behave in health and disease
Integrative NMR and biophysical studies of fibrillar protein assemblies in health and disease
['FUNDING_OTHER'] · RUTGERS, THE STATE UNIV OF N.J. · NIH-10831993
This study is looking at how two important proteins, collagen and α-synuclein, behave and interact, which could help us understand their roles in keeping us healthy and how they might be involved in diseases like Parkinson's.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUTGERS, THE STATE UNIV OF N.J. (nih funded) |
| Locations | 1 site (PISCATAWAY, UNITED STATES) |
| Trial ID | NIH-10831993 on ClinicalTrials.gov |
What this research studies
This research investigates the behavior of two types of protein fibrils: collagen, which is crucial for cellular function, and α-synuclein, which is linked to diseases like Parkinson's. By examining how these proteins self-assemble and interact at various scales, the research aims to uncover the molecular dynamics that influence their roles in health and disease. The study employs advanced techniques to analyze the properties of these fibrils, focusing on their conformational changes and interactions over time. This could lead to a better understanding of how these proteins contribute to normal bodily functions and disease processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by synucleinopathies, such as Parkinson's disease, as well as those with conditions related to collagen dysfunction.
Not a fit: Patients with unrelated health conditions or those not affected by protein misfolding disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the mechanisms of diseases associated with protein misfolding, potentially paving the way for innovative treatments.
How similar studies have performed: Previous research has shown promising results in understanding protein fibril dynamics, suggesting that this approach could yield valuable insights.
Where this research is happening
PISCATAWAY, UNITED STATES
- RUTGERS, THE STATE UNIV OF N.J. — PISCATAWAY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BAUM, JEAN S — RUTGERS, THE STATE UNIV OF N.J.
- Study coordinator: BAUM, JEAN S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.