Understanding how protein degradation affects T cell function and memory
Official title: The role for ER associated degradation (ERAD) in T cell homeostasis and memory
Funded at University of Michigan at Ann Arbor · NIH-11019843 · Data updated 2026-11-12
This study is looking at how a process in our cells helps keep immune T cells healthy and strong, which is important for fighting off viruses and cancer, and it could lead to better treatments for these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | March 17, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $493,107 |
| NIH project number | 5R01AI165533-03 |
| Project ID | NIH-11019843 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that affect T cell function, such as certain cancers or chronic viral infections.
✕Less likely to help
Patients with conditions unrelated to T cell function or those who do not have a significant immune response issue may not benefit from this research.
What this research studies
This research investigates the role of endoplasmic reticulum associated degradation (ERAD) in regulating CD8+ T cells, which are essential for fighting viral infections and tumors. The study focuses on how maintaining protein homeostasis influences T cell survival and function, particularly in the context of immune responses. By using mouse models to disrupt the ERAD pathway, researchers aim to uncover new insights into T cell behavior and memory formation, which could lead to improved immunotherapies.
Why it matters
Potential benefit: If successful, this research could enhance the effectiveness of immunotherapies for cancer and viral infections by improving T cell responses.
How similar studies have gone: Previous research has shown promising results in understanding T cell responses through similar mechanisms, indicating potential for success in this area.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Carty, Shannon a. — University of Michigan at Ann Arbor
- Study coordinator: Carty, Shannon a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.