Understanding how protein degradation affects T cell function and memory
The role for ER associated degradation (ERAD) in T cell homeostasis and memory
['FUNDING_R01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11019843
This study is looking at how a process in our cells helps keep immune T cells healthy and strong, which is important for fighting off viruses and cancer, and it could lead to better treatments for these conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11019843 on ClinicalTrials.gov |
What this research studies
This research investigates the role of endoplasmic reticulum associated degradation (ERAD) in regulating CD8+ T cells, which are essential for fighting viral infections and tumors. The study focuses on how maintaining protein homeostasis influences T cell survival and function, particularly in the context of immune responses. By using mouse models to disrupt the ERAD pathway, researchers aim to uncover new insights into T cell behavior and memory formation, which could lead to improved immunotherapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that affect T cell function, such as certain cancers or chronic viral infections.
Not a fit: Patients with conditions unrelated to T cell function or those who do not have a significant immune response issue may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance the effectiveness of immunotherapies for cancer and viral infections by improving T cell responses.
How similar studies have performed: Previous research has shown promising results in understanding T cell responses through similar mechanisms, indicating potential for success in this area.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CARTY, SHANNON A. — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: CARTY, SHANNON A.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.