Understanding how protein degradation affects heart health
Official title: Roles for endoplasmic reticulum associated degradation (ERAD) in Myocardial Proteostasis
Funded at University of Arizona · NIH-10939599 · Data updated 2026-11-12
This study is looking at how a process that helps break down proteins in heart cells can affect heart health, especially during problems like reduced blood flow, and aims to find ways to protect heart cells and help them recover better after issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $723,894 |
| NIH project number | 1R01HL174576-01 |
| Project ID | NIH-10939599 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of heart disease or those at risk of myocardial infarction.
✕Less likely to help
Patients with non-cardiac related health issues or those without any history of heart disease may not benefit from this research.
What this research studies
This research investigates the role of a specific protein degradation process, known as endoplasmic reticulum associated degradation (ERAD), in maintaining protein balance within heart cells. By studying how imbalances in this process contribute to heart diseases, the research aims to uncover mechanisms that lead to heart damage during conditions like ischemia. The approach involves using animal models to observe the effects of manipulating certain proteins, particularly Vimp, on heart cell function and overall heart health. Patients may benefit from insights gained about how to protect heart cells from damage and improve recovery after heart-related events.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for protecting heart cells and improving outcomes for patients with heart diseases.
How similar studies have gone: Previous research has shown promising results in understanding protein degradation mechanisms in other diseases, suggesting potential for success in this area as well.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Glembotski, Chris — University of Arizona
- Study coordinator: Glembotski, Chris
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.