Understanding how protein degradation affects heart health
Roles for endoplasmic reticulum associated degradation (ERAD) in Myocardial Proteostasis
['FUNDING_R01'] · UNIVERSITY OF ARIZONA · NIH-10939599
This study is looking at how a process that helps break down proteins in heart cells can affect heart health, especially during problems like reduced blood flow, and aims to find ways to protect heart cells and help them recover better after issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ARIZONA (nih funded) |
| Locations | 1 site (TUCSON, UNITED STATES) |
| Trial ID | NIH-10939599 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a specific protein degradation process, known as endoplasmic reticulum associated degradation (ERAD), in maintaining protein balance within heart cells. By studying how imbalances in this process contribute to heart diseases, the research aims to uncover mechanisms that lead to heart damage during conditions like ischemia. The approach involves using animal models to observe the effects of manipulating certain proteins, particularly Vimp, on heart cell function and overall heart health. Patients may benefit from insights gained about how to protect heart cells from damage and improve recovery after heart-related events.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of heart disease or those at risk of myocardial infarction.
Not a fit: Patients with non-cardiac related health issues or those without any history of heart disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for protecting heart cells and improving outcomes for patients with heart diseases.
How similar studies have performed: Previous research has shown promising results in understanding protein degradation mechanisms in other diseases, suggesting potential for success in this area as well.
Where this research is happening
TUCSON, UNITED STATES
- UNIVERSITY OF ARIZONA — TUCSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GLEMBOTSKI, CHRIS — UNIVERSITY OF ARIZONA
- Study coordinator: GLEMBOTSKI, CHRIS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.