Understanding how protein degradation affects cell behavior in plants
Official title: Control of protein degradation and transcriptional dynamics in the auxin response
Funded at University of Washington · NIH-11077695 · Data updated 2026-11-12
This study is looking at how the breakdown of proteins affects how cells behave and develop in plants, which could help us understand similar processes in other living things and might lead to new treatments for diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | June 10, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $373,351 |
| NIH project number | 5R35GM148135-03 |
| Project ID | NIH-11077695 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals interested in advancements in cancer treatment and those affected by conditions related to cellular behavior.
✕Less likely to help
Patients with conditions unrelated to cellular behavior or those not interested in plant biology may not receive direct benefits from this research.
What this research studies
This research investigates the role of protein degradation in regulating transcriptional responses that influence cell behavior and development in multicellular organisms, particularly plants. By using a model system based on the auxin response, the researchers aim to uncover how the timing of protein turnover can lead to changes in cell fate. The study employs advanced techniques to analyze the molecular mechanisms involved in this process, which could have implications for understanding similar processes in other eukaryotes. Patients may benefit from insights gained that could inform new therapeutic strategies for diseases related to cellular behavior, including cancers.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for manipulating cell behavior, which may have applications in treating various diseases, including cancer.
How similar studies have gone: Other research has shown success in using similar molecular mechanisms to influence cell behavior, indicating that this approach has potential for impactful discoveries.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Nemhauser, Jennifer L — University of Washington
- Study coordinator: Nemhauser, Jennifer L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.