Understanding how protein complexes interact with DNA and chromatin
The Role of Dynamics in Regulating Multi-Activity Protein Complexes and Chromatin
This study is looking at how certain proteins work with DNA to help control important processes in our cells, like reading genes and fixing DNA, which could help us understand problems that lead to developmental disorders and cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Dallas NIH-funded |
| Lab location | 1 site (Richardson, United States) |
| Project ID | NIH-11090022 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which protein complexes interact with chromatin to regulate essential cellular processes like transcription, DNA repair, and replication. It focuses on the balance of nucleosome assembly and disassembly, which controls access to genomic DNA in eukaryotic cells. By employing advanced biophysical techniques, particularly hydrogen-deuterium exchange coupled with mass spectrometry, the study aims to uncover the molecular details of how chromatin regulators influence chromatin structure and dynamics. This understanding could provide insights into the disruptions that lead to developmental disorders and cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with developmental disorders or cancers associated with altered transcriptional profiles and genomic instability.
Not a fit: Patients with conditions unrelated to chromatin dynamics or those not experiencing genomic instability may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating cancers and developmental disorders caused by chromatin dysregulation.
How similar studies have performed: Other research has shown success in understanding chromatin dynamics and its implications in various diseases, suggesting that this approach has the potential for meaningful advancements.
Where this research is happening
Richardson, United States
- University of Texas Dallas — Richardson, United States (Active)
Researchers
- Principal investigator: D'arcy, Sheena — University of Texas Dallas
- Study coordinator: D'arcy, Sheena
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.