Understanding how protein changes affect their function
Official title: DMS/NIGMS 1: Topological Dynamics Models of Protein Function
Funded at Arizona State University-Tempe Campus · NIH-10934374 · Data updated 2026-11-12
This study is looking at how changes in proteins can affect how they work, with the goal of finding new ways to design proteins that could help treat diseases and improve health for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project start | September 25, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $197,205 |
| NIH project number | 5R01GM152735-02 |
| Project ID | NIH-10934374 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic mutations affecting protein function or those at risk for diseases related to protein dynamics.
✕Less likely to help
Patients with conditions unrelated to protein function or dynamics may not receive any benefit from this research.
What this research studies
This research investigates how mutations in protein sequences can alter their dynamics and functions. By employing innovative mathematical and physical modeling techniques, the study aims to create a framework that links protein structure, dynamics, and function. This approach could lead to advancements in engineering proteins for therapeutic purposes, particularly in addressing diseases and viral evolution. Patients may benefit from insights that could lead to new treatments or preventive measures against various health conditions.
Why it matters
Potential benefit: If successful, this research could lead to the development of engineered proteins that effectively treat diseases and combat viral outbreaks.
How similar studies have gone: Previous research has shown promise in using mathematical modeling to understand protein dynamics, suggesting that this approach could yield significant insights.
Where this research is happening
-
Arizona State University-Tempe Campus
Tempe, United States Active
Researchers
- Principal investigator: Panagiotou, Eleni — Arizona State University-Tempe Campus
- Study coordinator: Panagiotou, Eleni
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.