Understanding how protein changes affect cell organization in cancers
The role of phosphorylation in the cellular organization of the proteome
This work explores how tiny changes to proteins, called phosphorylation, organize cells and how this process goes wrong in diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11161373 on NIH RePORTER |
What this research studies
Our cells constantly receive signals and make decisions, often through a process called protein phosphorylation. This process helps proteins function correctly and is vital for all cell activities. When phosphorylation doesn't work right, it can lead to many diseases, including cancers. This project aims to discover how these protein changes regulate the overall organization of cells. We want to identify specific phosphorylation sites important for protein functions and understand how they control cell structure at multiple levels.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but focuses on understanding the basic mechanisms of diseases like cancer.
Not a fit: Patients seeking immediate treatment or clinical trial participation would not directly benefit from this early-stage basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of how diseases like cancer develop at a fundamental cellular level, potentially opening doors for new treatment strategies.
How similar studies have performed: Previous research has successfully developed methods to study protein phosphorylation, and this project builds upon that established knowledge and methodology.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Villen, Judit — University of Washington
- Study coordinator: Villen, Judit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.