Understanding how protein changes affect cell function and disease
Official title: Complexity of Protein Tyrosine Phosphatase Oxidation
Funded at State University of New York at Albany · NIH-11089448 · Data updated 2026-11-12
This study is looking at how certain proteins in our cells change when they are exposed to stress, which could help us understand diseases better and find new ways to treat them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Albany NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project start | June 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $375,753 |
| NIH project number | 5R35GM153449-02 |
| Project ID | NIH-11089448 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to cellular signaling dysfunction, such as certain cancers or metabolic disorders.
✕Less likely to help
Patients with diseases unrelated to protein signaling or oxidative stress may not benefit from this research.
What this research studies
This research investigates the role of protein tyrosine phosphatases (PTPs) in cellular signaling and how their oxidation affects cell function and disease progression. By examining the reversible oxidation of specific proteins, the study aims to uncover mechanisms that regulate cellular responses to oxidative stress. The approach involves detailed biochemical analyses and in vivo studies to characterize the effects of these processes on cellular signaling pathways. Patients may benefit from insights gained that could lead to new therapeutic strategies targeting these pathways.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases linked to dysfunctional cellular signaling.
How similar studies have gone: Previous research has shown promising results in understanding protein signaling mechanisms, indicating potential for success in this area.
Where this research is happening
-
State University of New York at Albany
Albany, United States Active
Researchers
- Principal investigator: Boivin, Benoit — State University of New York at Albany
- Study coordinator: Boivin, Benoit
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.