Understanding how protein changes affect aging
Defining the landscape and mechanisms of protein redox regulation during aging
['FUNDING_R01'] · DANA-FARBER CANCER INST · NIH-11134578
This work explores how chemical changes in proteins contribute to the aging process and age-related health issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DANA-FARBER CANCER INST (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11134578 on ClinicalTrials.gov |
What this research studies
Our bodies' tissues are constantly undergoing changes, including modifications to proteins that are regulated by reactive oxygen species, or ROS. When these ROS signals are out of balance, it can lead to the decline of tissues as we age. This project aims to map out these specific protein changes in detail, especially those linked to age-related diseases. We hope to discover how these protein networks are organized and function, and how interventions that extend lifespan might affect them.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage, but future clinical applications may benefit individuals experiencing age-related health decline.
Not a fit: Patients not experiencing age-related conditions or those seeking immediate treatment options would not directly benefit from this basic science investigation.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of aging and age-related diseases, potentially paving the way for new strategies to promote healthy aging.
How similar studies have performed: While the specific technology for mapping protein changes is novel, the concept of redox regulation in aging is a long-standing area of biological inquiry with existing research supporting its importance.
Where this research is happening
BOSTON, UNITED STATES
- DANA-FARBER CANCER INST — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHOUCHANI, EDWARD THOMAS — DANA-FARBER CANCER INST
- Study coordinator: CHOUCHANI, EDWARD THOMAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.