Understanding how protein buildup spreads in Lewy Body Dementia
Mechanisms of spreading proteinopathy in Lewy Body Dementia
This study is looking at how certain proteins spread in the brains of people with Lewy Body Dementia, using mice to see how other brain changes might affect this process, which could help us understand the disease better and find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10795732 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the spread of protein aggregates, specifically alpha-synuclein, in Lewy Body Dementia. By using advanced imaging techniques in mouse models, the team aims to explore how the presence of beta-amyloid plaques and tau tangles influences the formation and spread of Lewy pathology in the brain. The study will provide insights into the interactions between different types of proteinopathies and their impact on neurodegeneration. This research could lead to a better understanding of disease progression and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Lewy Body Dementia or related neurodegenerative conditions.
Not a fit: Patients with other forms of dementia that do not involve Lewy pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for slowing or preventing the progression of Lewy Body Dementia.
How similar studies have performed: Previous research has shown promising results in understanding proteinopathies in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Unni, Vivek — Oregon Health & Science University
- Study coordinator: Unni, Vivek
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.