Understanding how protein assembly affects inflammation in aging
Evaluating the role of protein self-assembly in the innate immune system
['FUNDING_OTHER'] · NORTHWESTERN UNIVERSITY · NIH-11007236
This study is looking at how certain proteins in our immune system might cause more inflammation as we get older, which could help us find new ways to prevent or treat age-related health issues.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY (nih funded) |
| Locations | 1 site (Chicago, UNITED STATES) |
| Trial ID | NIH-11007236 on ClinicalTrials.gov |
What this research studies
This research investigates the role of protein self-assembly in the innate immune system, particularly how it contributes to chronic inflammation as people age. It focuses on understanding the molecular mechanisms that lead to increased proinflammatory signals in monocytes, which are immune cells that play a crucial role in the body's response to inflammation. By exploring whether these protein assemblies can sustain a proinflammatory state, the research aims to uncover potential targets for preventing and treating age-related diseases. The findings could help clarify why inflammation increases with age and how it affects overall health.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related inflammatory conditions or diseases.
Not a fit: Patients who are younger and do not have any age-related inflammatory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating age-related diseases linked to chronic inflammation.
How similar studies have performed: Previous research has shown promising results in understanding inflammation and immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
Chicago, UNITED STATES
- NORTHWESTERN UNIVERSITY — Chicago, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RODRIGUEZ GAMA, ALEJANDRO — NORTHWESTERN UNIVERSITY
- Study coordinator: RODRIGUEZ GAMA, ALEJANDRO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adult onset diabetes, Adult-Onset Diabetes Mellitus, age associated disease, age associated disorder, age dependent disease