Understanding how protein and RNA sequences affect their function and behavior
Official title: Discovering interpretable mechanisms explaining high dimensional biomolecular data
Funded at Ut Southwestern Medical Center · NIH-10910030 · Data updated 2026-11-12
This study is looking at how the building blocks of proteins and RNA shape their structure and function, which is important for understanding different health issues, and it uses advanced computer techniques to help predict how these complex molecules behave.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $410,000 |
| NIH project number | 5R35GM150897-02 |
| Project ID | NIH-10910030 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by neurodegenerative diseases, particularly those with Alzheimer's disease.
✕Less likely to help
Patients with conditions unrelated to protein misfolding or aggregation may not benefit from this research.
What this research studies
This research investigates how the sequences of proteins and RNA influence their folding, aggregation, and overall function, which is crucial for understanding various health conditions. By employing advanced computational methods, including statistical physics and innovative neural networks, the project aims to uncover predictive principles that can explain the behavior of complex biomolecules. This approach seeks to provide insights into proteins that are difficult to study experimentally, particularly those that are intrinsically disordered. The goal is to create models that not only predict outcomes but also offer interpretable insights into the underlying mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for diseases related to protein misfolding, such as Alzheimer's.
How similar studies have gone: Previous research has shown promise in using computational methods to understand protein behavior, indicating that this approach could yield valuable insights.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Lin, Milo — Ut Southwestern Medical Center
- Study coordinator: Lin, Milo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.