Understanding how protein acetylation affects bacteria
Official title: Investigation of the physiological significance of protein acetylation in Bacillus subtilis
Funded at Rowan University · NIH-10873748 · Data updated 2026-11-12
This study looks at how a tiny change in proteins, called acetylation, affects how a common bacterium called Bacillus subtilis works, especially focusing on a protein similar to those found in our cells, to learn more about how it helps the bacteria manage important tasks like gene activity and organizing their genetic material.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rowan University NIH-funded |
| Lab location | 1 site (Glassboro, United States) |
| Project start | September 1, 2020 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $365,086 |
| NIH project number | 5R35GM138303-05 |
| Project ID | NIH-10873748 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would be individuals interested in the molecular biology of bacteria or those affected by bacterial infections.
✕Less likely to help
Patients with conditions unrelated to bacterial infections or those not interested in microbiological research may not receive any benefit from this research.
What this research studies
This research investigates the role of protein acetylation in the bacterium Bacillus subtilis, focusing on how this modification influences various cellular functions. By studying a specific protein known as HBsu, which is similar to histones in eukaryotes, the research aims to uncover the mechanisms behind acetylation and its impact on bacterial physiology. The approach involves identifying acetylation sites and understanding their significance in cellular processes such as gene expression and chromosome organization.
Why it matters
Potential benefit: If successful, this research could lead to new insights into bacterial behavior and potentially inform the development of novel antibacterial strategies.
How similar studies have gone: While the study of protein acetylation in bacteria is a relatively new field, previous research has shown promising results in understanding similar modifications in other organisms.
Where this research is happening
-
Rowan University
Glassboro, United States Active
Researchers
- Principal investigator: Carabetta, Valerie Jean — Rowan University
- Study coordinator: Carabetta, Valerie Jean
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.